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Effect of serum ferritin level on pulmonary dysfunction and sensitisation to aeroallergens in paediatric beta thalassemia major

Soheila Kianpour Rad 1*, Seyed Mohammad Fathi 2, Hadi Mousakhani 3 1 Qazvin University of Medical Science, Qazvin, Iran 2 Allergist& Clinical Immunologist ,Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran 3 Hematologist & Oncologist,Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

The beta thalassemia major (BTM) is the most severe type of thalassemia.
Outlining steps in such health problems are vital, since affected children who need repeated transfusions undergo deposition of iron in their different body tissue, causing various dysfunctions, including lung impairment. 33 BTM patients were examined by Pulmonary Function Tests (PFTs) and also skin Prick test and the serum ferritin level was checked. The study demonstrated that 60.5% of the patients had normal PFTs, 21.33% showed restrictive, 12.12% obstructive pattern and two (6.06%) had the mixed pattern and the predominant pulmonary dysfunction was restrictive. Severity of the restrictive pattern has significant correlation with serum ferritin level but not with age, sex, Body Mass Index (BMI) and duration of transfusion therapy. The majority of Splenectomised (SPL) patients had restrictive pattern. Only 5 patients had positive prick test which shows that BTM did not relate to their positive prick test. Cell, Gene and Therapy, Vol.1, Number 1, April 1st, 2019; 64-72

Keywords : Beta thalassemia, Paediatrics, pulmonary dysfunction, Serum ferritin, Aeroallergens


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